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Global Antimicrobial Resistance Prevention and Control

The rise of antimicrobial resistance (AMR) is considered a global patient safety issue and a major public health concern. Compounding the threat of AMR, hospital acquired infections further contribute to adverse patient outcomes, and in many instances are caused by highly resistant organisms.

Effective systems, policies, and procedures to accurately detect, monitor, and prevent AMR and hospital acquired infections are essential. These systems include robust laboratory-based surveillance of priority pathogens, effective infection prevention and control practices, strong antimicrobial stewardship, and facility-based surveillance of hospital acquired infections.

Building the capacity to implement and sustain these systems and practices is thus critical to effectively respond to the public health threats posed by AMR.

Program Director(s)

Jay Graham


Antimicrobial Resistance Transmission Associated with Small-scale Food-Animal Production

Community acquired antimicrobial resistance (AMR) constitutes an increasingly critical human health threat. We have identified small-scale food-animal production animals (i.e. livestock raised for meat and dairy products), where antimicrobials are regularly used for growth promotion, disease prevention and/or disease treatment, to be associated with community acquired AMR in humans. This study will measure the extent to which AMR spills over from food-animals to young children and elucidate the risk factors, that increase AMR transmission. The study will also quantify the biological mechanisms – clonal dissemination versus horizontal gene transfer – that affect the spread of AMR between food-animals and young children.

India Antimicrobial Resistance Detection, Prevention and Control Program

The goal of this project is to support CDC India and the Tamil Nadu Directorate of Public Health and Preventive Medicine to expand infection prevention control (IPC) activities to selected primary health centers in the state. Additionally, we will work with our partners to specifically target reductions in maternal and neonatal infections in currently supported district hospitals.

Here's How We're Making a Difference

Combating Antibiotic Resistance through Detection, Treatment and Prevention

Photo by Drew Hays on UnsplashTo combat the growing threat of antibiotic resistance, PHI is working in India to advance the detection, treatment and prevention of critical drug resistant pathogens. In Tamil Nadu, PHI-India has documented elevated levels of pathogenic bacteria resistant to antibiotics used as last lines of defense in human medicine.

PHI-India has also convened more than 100 government and private sector physicians to raise awareness about effective infection prevention and control, and they are working to develop a standardized protocol for surveillance of healthcare-associated infections. Under the project, a state-level Antimicrobial Resistance (AMR) Committee was developed and launched to improve AMR surveillance and control. An analysis of district hospital AMR data was also conducted and indicates a high proportion of resistance to last-line antibiotics among outpatients. 

Ultimately, the goal of the project is to pilot a program that will be scaled up across the state of Tamil Nadu, India, with potential health implications for the entire population of over 70 million people.