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New preliminary research, produced in part by PHI's Child Health and Development Studies, finds that grandparents' behavior could be linked to an increased risk of autism in grandchildren.

3 generations of families included in CHDS research

PHI’s Child Health and Development Studies, in collaboration with the California Department of Public Health Environmental Health Investigations Branch and the Department of Developmental Services, have found preliminary evidence to support a role of perinatal grandparental behavioral factors in risk of Autism Spectrum Disorder (ASD) in grandchildren.

Results will be presented in an abstract at the International Society for Autism Research Conference in 2020.

Larger epidemiologic studies with information on the grandparents’ and parents’ generations and animal studies are needed to confirm these findings and investigate biological mechanisms, including epigenetic alterations to the germ line.

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