In the News

PHI’s Dr. Barbara Cohn Discusses the Effects of Environmental Exposures During Pregnancy

During a Mayo Clinic conference which brought together exposome experts from across the globe, PHI’s  Dr. Barbara Cohn discussed how cumulative environmental exposures during pregnancy can affect mothers and three generations of their offspring.

  • NIEHS Environmental Factor
Pregnant woman holding a picture of her baby's ultrasound

“Explore the Exposome: The Next Frontier of Individualizing Medicine” was the title of a Mayo Clinic conference that brought together experts from around the world, including NIEHS leaders and grant recipients, Nov. 2-3 in Rochester, Minn. Participants explored how the exposome — the totality of a person’s exposures throughout life and their corresponding biological effects — can advance human health on a personalized level.

Accelerating discoveries

“We’ve made significant progress in mapping the human genome and understanding the role of genes in diseases, but genetics only accounts for approximately 10% to 15% of diseases,” said Konstantinos Lazaridis, M.D., executive director of the Mayo Clinic’s Center for Individualized Medicine, in a statement promoting the event. “The key to accelerating further discoveries in individualized medicine lies in putting the exposome under the microscope,” he added.

“To predict individualized health outcomes, you have to factor environmental exposures into the equation,” NIEHS Director Rick Woychik, Ph.D., told attendees.

Bright future for exposomics

“Some people say, ‘It’s impossible to measure everything that a person has been exposed to throughout their lifetime, so why bother?’” noted NIEHS grantee and Columbia University professor Gary Miller, Ph.D.

Several years ago, when he taught at Emory University, Miller and his colleague Dean Jones, Ph.D., an NIEHS grantee, who also spoke at the conference, sought to bring clarity to exposomics and show what is possible through such research. Exposome epidemiology is now beginning to identify health risks based on biomarkers of environmental exposures, noted Jones.

“The key to successful use of precision medicine will be to detect responses to exposures and intervene to improve health outcomes,” he added.

Other NIEHS grantee contributions

Susan Sumner, Ph.D., director of the metabolomics and exposome laboratory at the University of North Carolina at Chapel Hill Nutrition Research Institute, discussed precision nutrition.

“In precision medicine, we often study how some individuals respond well to a drug treatment while others do not have a positive response,” she said. “In precision nutrition, we study individuals’ different nutrient requirements, or their different responses to intake. How an individual responds to nutrients, or to a diet, is related to their health status and to inherited genetics and lifetime exposures. We aim to understand how exposures, or co-exposures, are related to individuals’ responses, and to use this information to discover biological mechanisms as well as pharmacological and nutritional targets.”

“Environmental exposures can influence genetically driven processes, often negatively,” added Miller. “But diet can sometimes help control genetic diseases.”

Barbara Cohn, Ph.D., from the Public Health Institute, described her work based on studies dating from the 1960s, which showed that cumulative exposures during pregnancy can affect at least three generations.”


Barbara Cohn
Pregnancy is a vulnerable window of susceptibility for mothers and their offspring. Barbara Cohn, PhD

Director, Child Health and Development Studies

Read the full story from NIEHS Environmental Factor.

Related Stories

Pregnancy Exposome A New Frontier in Personalized Medicine / Bio-IT World

More Updates

Work With Us

You change the world. We do the rest. Explore fiscal sponsorship at PHI.

Bring Your Work to PHI

Support Us

Together, we can accelerate our response to public health’s most critical issues.


Find Employment

Begin your career at the Public Health Institute.

See Jobs

Aerial view of wildfire smoke


Wildfires & Extreme Heat: Resources to Protect Yourself & Your Community

Communities across the U.S. and around the world are grappling with dangerous wildfires and extreme heat. These threats disrupt and uproot communities and pose serious risks to environmental and community health—from rising temperatures, unhealthy air pollutants, water contamination and more. Find PHI tools, resources and examples to help communities take action and promote climate safety, equity and resiliency.

Get started

Continue to