In the News

Will Synthetic Alcohol Mean the End of Hangovers?

A brain scientist is working on creating Alcarelle, a synthetic alcohol that will allow you to feel the good effects of drinking, without the hangover. But Sarah Zemore of PHI’s Alcohol Research Group explains why she is not convinced that Alcarelle will work as planned, and describes her concerns that using the substance may lead to the same risky and dangerous behaviors as alcohol.

  • WHYY - The Pulse
a drink glass filled with alcohol, surrounded by white smoke

In an underground lab in the English countryside, a top brain scientist has been working on synthetic alcohol – a drink that can get you tipsy without the hangover. David Nutt has been testing this new creation on himself.

Nutt, currently professor of neuropsychopharmacology at Imperial College London, was the UK government’s drugs adviser in the late 2000s. But he was fired in 2009 for claiming that alcohol is more dangerous than ecstasy or LSD. The following year, he published a study showing that booze is more harmful to society than heroin or crack cocaine.

“Alcohol has always been one of my biggest research interests,” Nutt said. “As a doctor, you’re always confronted by the problems of alcohol. Every time you go on the ward, you see someone who’s been damaged by alcohol. So I’ve always wanted to give young people an alternative to this addictive, toxic substance, which in the end could — well, we know will — kill 3 ½ million people a year prematurely.”

The alternative he’s working on now is a molecular compound called Alcarelle. The plan is for Alcarelle to be used in various kinds of drinks—instead of alcohol. According to Nutt, the compound will allow you to feel the good effects of booze, without the hangover.

“The science of Alcarelle is based on an understanding, a deep understanding of the science of alcohol,” Nutt said. “Over the last 50 years, neuroscience has made major progress in understanding what alcohol does in the brain.”

Not everyone sees the potential of an alternative to alcohol, however.

“I don’t think the premise that we can fully separate the positive and negative effects of a synthetic substance on the brain can be fully supported by what we know about brain function, alcohol and addiction,” said Sarah Zemore, senior scientist at the Alcohol Research Group, a Public Health Institute nonprofit based in California.

Zemore is not convinced that Alcarelle will work.

They’re targeting sociability and relaxation, but how do you do that without targeting disinhibition? I can’t imagine how you could achieve those effects without disinhibiting a person. And so if that happens, then people are prone to make risky and poor decisions just as they do with alcohol. So they may be more likely to engage in unsafe behaviors, unsafe sex, violence, and criminal activity, or behaviors that are simply dangerous.

Sarah Zemore of PHI’s Alcohol Research Group

We’re a few years away from being able to order a drink with Alcarelle in it. The compound first needs to go through lots of rigorous safety testing, and there are several hurdles to clear.

Listen to the Story

Click below for the transcript from WHYY.

Originally published by WHYY - The Pulse

More Updates

Work With Us

You change the world. We do the rest. Explore fiscal sponsorship at PHI.

Bring Your Work to PHI

Support Us

Together, we can accelerate our response to public health’s most critical issues.


Find Employment

Begin your career at the Public Health Institute.

See Jobs

Kids in a school playground


Donate to PHI Today to Build a Healthier World for Tomorrow

The last few years have been immensely challenging for communities around the globe—in some cases, setting back public health gains by years or decades. But these last few years have also demonstrated what works: Sustained investments in communities, health and equity, and policy change to support them. Now is the time to strengthen these successes, to ensure that no community falls behind.

Donate to PHI

Continue to