Physician’s Weekly: Study Using Data from PHI’s California Cancer Registry Explores How Ethnicity Impacts Mortality in Early-Onset Colorectal Cancer

“Mortality from early-onset colorectal cancer (EOCRC) was higher among California patients who were Hispanic, Native Hawaiian or Other Pacific Islander, non-Hispanic Black, and Southeast Asian compared with non-Hispanic White, according to study findings published online in JAMA Network Open.

“Neighborhood socioeconomic status and insurance status attenuated the differences in EOCRC mortality when factored into the analysis,” researchers wrote.

Researchers used data from the California Cancer Registry to investigate racial and ethnic differences in mortality rates among patients diagnosed with colorectal cancer before age 50 years. The study included 22,834 patients diagnosed with EOCRC between 2000 and 2019. Among them, 53.5% were male, and the median follow-up was 4.2 years.

Some 15.5% of patients were Asian American, 30.2% were Hispanic, 0.6% were Native Hawaiian or Other Pacific Islander, 0.5% were non-Hispanic American Indian or Alaska Native, 7.3% were non-Hispanic Black, and 45.9% were non-Hispanic White.

Racial and ethnic disparities in mortality were evident, researchers reported, particularly for patients who were Native Hawaiian or Other Pacific Islander and non-Hispanic Black. Adjusted hazard ratios for EOCRC mortality were 1.34 for patients who were Native Hawaiian or Other Pacific Islander and 1.18 for patients who were non-Hispanic Black compared with patients who were non-Hispanic White.”

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Originally published by Physician's Weekly